'Bundle them high, protect them cheap': IP and commoditization

Wear them, forget them.

Off-label prescriptions: how to identify them, frame them, announce them and monitor them in practice?

Following the Mediator crisis and the passage of the Health and Safety Law of December 2011, off-label prescriptions are a real concern shared by all those involved in healthcare system. Off-label, in the strictest sense of the term, is defined as all prescriptions that do not correspond to the summary of product characteristics (SPC), particularly those that fail to comply with the indications...

Build them up and break them down

Tight junctions (TJs) of cells expressing simple epithelial polarity have been extensively studied, but less is known about TJs of cells expressing complex polarity. In this paper we analyzed, TJs of four different lines, that form bile canaliculi (BC) and express typical hepatocyte polarity; WIF-B9, 11-3, Can 3-1, Can 10. Striking differences were observed in claudin expression. None of the ce...

O3: Children are Not Small Adults! What should be done to Better Protect Them?

Road Traffic injuries are known as the most prevalent childhood injury and besides being the greatest cause of child mortality, place an extraordinary burden on health care system. Children’s limitation in cognitive, physical and social development makes them more vulnerable in road traffic injuries than adults. Their small structure cause challenges to see and be seen and their risk taki...

Make them, break them, and catch them: studying rare ubiquitin chains.

Two studies in this issue, Kristariyanto et al. (2015) and Michel et al. (2015), describe innovative ways to produce large quantities of atypical K29 and K33 ubiquitin chains and report structures and mechanisms of chain-specific recognition.